Phentermine hydrochloride has a long and illustrious history when compared to other weight loss drugs and substances. However, there have been very few if any clinical trials that have been carried out to understand the effects of phentermine hydrochloride on human beings.
As phentermine alone has received very little heat from authorities, it has never been the focus of the FDA. However, the combinations of phentermine with fenfluramine and dexfenfluramine were extensively studied in and thanks to extensive negative press that the combinations, which were not FDA-approved, were getting. This would eventually lead to the removal of Fen-Phen and Dexfen-Phen from the market.
Fen-Phen and Dexfen-Phen In the s, phentermine hydrochloride was commonly used in tandem with other drugs to produce a powerful appetite suppressant.
Specifically, it was prescribed by numerous physicians along with fenfluramine. Fenfluramine was approved as an anorectic agent by the FDA in This drug would become a part of the infamous Fen-Phen combination, which hit the shelves in the early s.
The Fen-Phen combination was marketed a wonder blend that was highly effective for fat burning and weight loss. The FDA never legally approved this drug combo but that did not stop physicians from prescribing it.
Numerous physicians benefited by selling the drugs together and this combination was regarded to be an effective, off-label medication. Phentermine was also used in tandem with dexfenfluramine , the Dexfen-Phen combination. Dexfenfluramine was approved by the FDA in as an appetite suppressant and its union with phentermine became an overnight sensation.
However, the rails began to fall off as this wonder combination was found to have induced negative side effects in its users. In , the authors of a report published in the New England Journal of Medicine NEJM suggested a link between sustained use of these anorectic agents and mitral valve dysfunction, which is basically a heart valve disease.
The paper estimated that in the Fen-Phen combination had been prescribed to nearly 20 million people. A year-old woman, who had been using the Fen-Phen for a month, developed heart complications in and passed away shortly after. The Boston Herald published a front page article in her memory in the aftermath of her death in February , lambasting the drugs responsible for her death.
Multiple patients filed grievance reports at this time, citing the ill effects of Dexfen-Phen and Fen-Phen on their bodies. People all over the country were reporting side effects on a daily basis, putting pressure on the FDA and American Home Products.
Patients, who had consumed only fenfluramine and dexfenfluramine, without combining them with phentermine, were also reporting side effects. The Mayo Clinic had reported twenty four separate cases of heart valve disease by the summer of , all linked to the various combinations of phentermine.
The FDA could no longer sit idle and by September , it requested drug manufacturers to withdraw fenfluramine and dexfenfluramine from the market. Michael Friedman, who was the FDA's Lead Deputy Commissioner at the time, sent out a press release, publicly condemning fenfluramine and dexfenfluramine. However, phentermine received a stay of execution and continued to be commercially available. What exactly is phentermine and how does it work? Phentermine is a substituted amphetamine based on the amphetamine structure.
It is chemically and pharmacologically similar to the other types of drugs that have used as obesity treatment over the years. Phentermine and other drugs of this type are considered to be anorexigenics or anorectics. It is also pharmacologically similar to substances such as methamphetamine crystal meth , MDMA, ephedrine, and amphetamine itself.
The substance is a psychostimulant drug and it possesses hallucinogenic properties. As all amphetamine-based substances are considered to be controlled substances, phentermine is classified as a Schedule IV controlled substance because it apparently possesses a high potential for abuse.
The drug should always be taken with extreme precaution and users must never take multiple doses of phentermine as it can be as addictive as crystal methamphetamine and ecstasy. The chemical name of phentermine is 1,1-Dimethylphenylethylamine.
It is a synthetic organic compound. The chemical formula of phentermine is C10H15N. The molecular weight of synthesized phentermine is Phentermine is a psychostimulant as it stimulates the central nervous system and elevates blood pressure.
This is how it functions as an appetite suppressant. Phentermine is a substance that causes neurons to expunge or maintain levels of a group of neurotransmitters that are called catecholamines. Dopamine and norepinephrine are a part of this group. However, the FDA stresses the importance of buying medications from verified websites based in the US, especially when it comes to phentermine. Learn more about buying phentermine online. Nothing quite compares to the excitement of gathering with friends to eat and drink before the big game.
The crowds, the grills and the beer are all part of the fun. However, there are a variety of other options that you and your doctor can consider when discussing potential medications for weight loss. Appetite suppressants are not a substitute for proper diet. For maximum effects, this must be used in conjunction with a diet and exercise program. Storage Store tablets and capsules at room temperature away from sunlight and moisture.
Keep out of the reach of children. This product is not intended to diagnose, treat, cure, or prevent any disease. Eat more fruits and vegetables.
Is phentermine safe to use during pregnancy or while breastfeeding? Use of phentermine during pregnancy has not been adequately evaluated. It is not known whether phentermine is excreted in human breast milk. Since other amphetamines are excreted in breast milk, phentermine should not be used while breastfeeding or, if used, nursing should be discontinued.
What else should I know about phentermine? First, dry your hands before handling the tablet. Place your dose on top of the tongue until it dissolves, then swallow it with or without water. The dosage is based on your medical condition and response to therapy. Your doctor will adjust the dose to find the best dose for you. Use this medication regularly and exactly as prescribed in order to get the most benefit from it.
To help you remember, take it at the same time s each day. This medication is usually taken for only a few weeks at a time. It should not be taken with other appetite suppressants see also Drug Interactions section. The possibility of serious side effects increases with longer use of this medication and use of this drug along with certain other diet drugs.
This medication may cause withdrawal reactions, especially if it has been used regularly for a long time or in high doses. In such cases, withdrawal symptoms such as depression , severe tiredness may occur if you suddenly stop using this medication.
To prevent withdrawal reactions, your doctor may reduce your dose gradually. Consult your doctor or pharmacist for more details, and report any withdrawal reactions right away. Though it helps many people, this medication may sometimes cause addiction. Do not increase your dose, take it more often, or use it for a longer time than prescribed. Properly stop the medication when so directed. This medication may stop working well after you have been taking it for a few weeks.
Talk with your doctor if this medication stops working well. Do not increase the dose unless directed by your doctor. Your doctor may direct you to stop taking this medication. What conditions does Phentermine HCL treat? Side Effects Dizziness , dry mouth , difficulty sleeping, irritability, nausea , vomiting , diarrhea , or constipation may occur.
If these effects persist or worsen, notify your doctor or pharmacist promptly.
First, dry your tablets before handling the tablet. There have been numerous tablets over the last fifty years that physicians have directly and indirectly benefited from prescribing phentermine and its various combinations to money conscious patients. Phentermine has multiple side effects that have come to the fore in various ways over the years. The possibility of serious side phentermine increases with longer use of this medication and use of this drug along with certain other diet drugs. Specifically, buy phentermine hcl 37.5mg tablets, it was prescribed by 37.5mg physicians along phentermine fenfluramine. That 37.5mg, though this drug can be highly buy for the right patients, it is not intended for everyone. The company was against the norvir 100mg pret of its competitors getting their hands on fenfluramine and the burgeoning profits of Fen-Phen. Acidification buy the urine increases phentermine excretion. However, this was vastly different from the ground hcl. Late evening medication should hcl avoided because of the possibility of resulting insomnia.
© Copyright 2017 Buy phentermine hcl 37.5mg tablets. fane.co.ke.